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Optimizing the compatibility of boronic acids for MCR is an interesting synthetic challenge, as the C─B bond is well known to react with common MCR starting materials and boronicintermediates under mild conditions,。

Boron containing compounds have not been widely studied inboronic Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the。

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